Open AccessPotential role of exercise-induced glucose-6-phosphate isomerase in skeletal muscle function
Author(s) -
Seong Eun Kwak,
Hwa Yong Shin,
Di Di Zhang,
JiHyun Lee,
Kyung Jin Yoon,
Joonsoo Bae,
Hyo Youl Moon,
Wook Song
Publication year - 2019
Publication title -
journal of exercise nutrition and biochemistry/journal of exercise nutrition and biochemisrty
Language(s) - English
Resource type - Journals
eISSN - 2233-6842
pISSN - 2233-6834
DOI - 10.20463/jenb.2019.0014
Subject(s) - skeletal muscle , c2c12 , medicine , endocrinology , downregulation and upregulation , myod , myocyte , biology , autocrine signalling , chemistry , receptor , myogenesis , biochemistry , gene
Recent studies have shown that glucose-6-phosphate isomerase (GPI)-which is a glycolysis interconversion enzyme-reduces oxidative stress. However, these studies are limited to tumors such as fibrosarcoma, and there are no studies that have examined the effects of exercise on GPI expression in mice skeletal muscle. Furthermore, GPI acts in an autocrine manner thorough its receptor, autocrine motility factor receptor (AMFR); therefore, we investigated expression level changes of secreted GPI from skeletal muscle in in vitro study to examine the potential role of GPI on skeletal muscle.