Acid sphingomyelinase inhibition alleviates muscle damage in gastrocnemius after acute strenuous exercise | Zendy

Young-Ik Lee | Zendy; YeaHyun Leem | Zendy

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Acid sphingomyelinase inhibition alleviates muscle damage in gastrocnemius after acute strenuous exercise

Author(s) -

Young-Ik Lee,

YeaHyun Leem

Publication year - 2019

Publication title -

physical activity and nutrition

Language(s) - English

Resource type - Journals

eISSN - 2233-6842

pISSN - 2233-6834

DOI - 10.20463/jenb.2019.0009

Subject(s) - sphingolipid , sphingomyelin , acid sphingomyelinase , endocrinology , medicine , creatine kinase , ceramide , skeletal muscle , gastrocnemius muscle , sphingomyelin phosphodiesterase , dysferlin , chemistry , inflammation , creatine , apoptosis , biochemistry , cholesterol

Strenuous exercise often induces skeletal muscle damage, which results in impaired performance. Sphingolipid metabolism contributes to various cellular processes, including apoptosis, stress response, and inflammation. However, the relationship between exercise-induced muscle damage and ceramide (a key component of sphingolipid metabolism), is rarely studied. The present study aimed to explore the regulatory role of sphingolipid metabolism in exercise-induced muscle damage.

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