Open AccessAcid sphingomyelinase inhibition alleviates muscle damage in gastrocnemius after acute strenuous exercise
Author(s) -
Young-Ik Lee,
Yea-Hyun Leem
Publication year - 2019
Publication title -
journal of exercise nutrition and biochemistry/journal of exercise nutrition and biochemisrty
Language(s) - English
Resource type - Journals
eISSN - 2233-6842
pISSN - 2233-6834
DOI - 10.20463/jenb.2019.0009
Subject(s) - sphingolipid , sphingomyelin , acid sphingomyelinase , endocrinology , medicine , creatine kinase , ceramide , skeletal muscle , gastrocnemius muscle , sphingomyelin phosphodiesterase , dysferlin , chemistry , inflammation , creatine , apoptosis , biochemistry , cholesterol
Strenuous exercise often induces skeletal muscle damage, which results in impaired performance. Sphingolipid metabolism contributes to various cellular processes, including apoptosis, stress response, and inflammation. However, the relationship between exercise-induced muscle damage and ceramide (a key component of sphingolipid metabolism), is rarely studied. The present study aimed to explore the regulatory role of sphingolipid metabolism in exercise-induced muscle damage.