Open AccessThe Kv7 channel activator, retigabine, induces vasorelaxation via an endothelial-independent pathway in male mouse aorta
Author(s) -
Hyun Namgoong,
Chaeeun Cho,
Sewon Lee
Publication year - 2018
Publication title -
journal of exercise nutrition and biochemistry/journal of exercise nutrition and biochemisrty
Language(s) - English
Resource type - Journals
eISSN - 2233-6842
pISSN - 2233-6834
DOI - 10.20463/jenb.2018.0024
Subject(s) - electrical impedance myography , sodium nitroprusside , vasodilation , aorta , vascular smooth muscle , chemistry , blood vessel , acetylcholine , medicine , pharmacology , nitric oxide , endocrinology , nitric oxide synthase , smooth muscle
Previous studies have indicated that Kv7 channels have an important role in the regulation of blood vessel reactivity, including in the coronary, renal, and cerebral arteries. The present studies examined whether Kv7 channels regulated vascular reactivity in the mouse aorta and investigated the mechanisms involved in the reactivity.