Open AccessSmallanthus sonchifolius leaf attenuates neuroinflammation
Author(s) -
Suji Baek,
Nan Hee Choi,
Kang Pa Lee,
Hyunjhung Jhun,
Jisu Kim
Publication year - 2018
Publication title -
journal of exercise nutrition and biochemistry/journal of exercise nutrition and biochemisrty
Language(s) - English
Resource type - Journals
eISSN - 2233-6842
pISSN - 2233-6834
DOI - 10.20463/jenb.2018.0014
Subject(s) - neuroinflammation , neuroprotection , nitric oxide , microglia , in vivo , lipopolysaccharide , nitric oxide synthase , tumor necrosis factor alpha , inflammation , neurodegeneration , chemistry , pharmacology , cyclooxygenase , immunology , medicine , biochemistry , endocrinology , biology , enzyme , disease , microbiology and biotechnology
Yacon, Smallanthus sonchifolius, has anti-hypertensive, anti-inflammatory, and anti-cancer potential. However, its neuroprotective and anti-neuroinflammatory effects are unknown. Moreover, activation of microglia has been considered a mechanism in the development of Alzheimer's disease. Therefore, the aim of this study was to determine the neuroprotective effects of an ethanolic yacon leaf extract (YLE) on lipopolysaccharide (LPS)-induced neuroinflammation in vitro and in vivo.