Open AccessResistance training increases fibroblast growth factor-21 and irisin levels in the skeletal muscle of Zucker diabetic fatty rats
Author(s) -
Hee-jae Kim,
Wook Song
Publication year - 2017
Publication title -
journal of exercise nutrition and biochemistry/journal of exercise nutrition and biochemisrty
Language(s) - English
Resource type - Journals
eISSN - 2233-6842
pISSN - 2233-6834
DOI - 10.20463/jenb.2017.0008
Subject(s) - skeletal muscle , fgf21 , endocrinology , medicine , resistance training , insulin resistance , myokine , fibroblast growth factor , chemistry , diabetes mellitus , receptor
Although the fibroblast growth factor-21 (FGF-21) and irisin roles are well demonstrated in metabolic disease, there have been no reports investigating the effect of resistance exercise on FGF-21 and irisin levels in diabetic skeletal muscles. Therefore, this study aimed to investigate the change of FGF-21 and irisin levels in various skeletal muscles, and their association with muscle strength, following 8 weeks of resistance training using Zucker diabetic fatty rats (type 2 diabetic animal models).