Open AccessEffects of creatine monohydrate supplementation and exercise on depression-like behaviors and raphe 5-HT neurons in mice
Author(s) -
Na-Ri Ahn,
Yea Hyun Leem,
Morimasa Kato,
HoWan Chang
Publication year - 2016
Publication title -
journal of exercise nutrition and biochemistry/journal of exercise nutrition and biochemisrty
Language(s) - English
Resource type - Journals
eISSN - 2233-6842
pISSN - 2233-6834
DOI - 10.20463/jenb.2016.09.20.3.4
Subject(s) - creatine , medicine , behavioural despair test , endocrinology , raphe , tail suspension test , raphe nuclei , dorsal raphe nucleus , depression (economics) , antidepressant , serotonin , serotonergic , receptor , macroeconomics , economics , hippocampus
The effects of creatine and exercise on chronic stress-induced depression are unclear. In the present study, we identified the effects of 4-week supplementation of creatine monohydrate and/or exercise on antidepressant behavior and raphe 5-HT expression in a chronic mild stress-induced depressed mouse model.