Open AccessJakyakgamcho-tang and Its Major Component, Paeonia Lactiflora, Exhibit Potent Anti-glycation Properties
Author(s) -
Jung-Hyun Kim,
Chan-Sik Kim,
Young Sook Kim,
Ik Soo Lee,
Jin Sook Kim
Publication year - 2016
Publication title -
journal of exercise nutrition and biochemistry/journal of exercise nutrition and biochemisrty
Language(s) - English
Resource type - Journals
eISSN - 2233-6842
pISSN - 2233-6834
DOI - 10.20463/jenb.2016.0049
Subject(s) - glycation , paeonia lactiflora , chemistry , bovine serum albumin , rhizome , in vitro , traditional medicine , ic50 , pharmacology , radix (gastropod) , inhibitory postsynaptic potential , medicine , biochemistry , biology , botany , alternative medicine , receptor , pathology
Advanced glycation end products (AGEs) have been implicated in the pathogenesis of diabetes and other age-related diseases. AGE inhibitors or breakers, such as aminoguanidine and alagebrium, have been proposed as therapeutic agents for AGE-related disorders. Jakyakgamcho-tang (JGT) is a well-known traditional herbal formula, which consists of the radix of Paeonia lactiflora Pallas (PR) and the radix and rhizome of Glycyrrhiza uralensis Fisch (GR). The purpose of this study was to evaluate the inhibitory and breaking activities of JGT, PR, and GR against AGEs.