Open AccessGreen synthesis of 2-aryl-4-phenyl-quınazolıne derıvatives promoted by lactıc acıd
Author(s) -
Belgheis Adrom,
Nourallah Hazeri,
Malek Taher Maghsoodlou,
Mojtaba Lashkari,
Maryam Fatahpour
Publication year - 2017
Publication title -
macedonian journal of chemistry and chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.19
H-Index - 16
eISSN - 1857-5625
pISSN - 1857-5552
DOI - 10.20450/mjcce.2017.1137
Subject(s) - aryl , ammonium acetate , chemistry , solvent , organic chemistry , reaction conditions , lactic acid , green chemistry , catalysis , reaction mechanism , alkyl , high performance liquid chromatography , biology , bacteria , genetics
An environmentally benign three-component synthetic method is described for the construction of 2-aryl-4-phenylquinazoline derivatives from the reaction between aldehydes, ammonium acetate, and 2-aminobenzophenone in the presence of lactic acid in a solvent-less media. The benefits of the reaction were good yields, a simple procedure, simple starting materials short reaction time, easy work-up, and cleaner reaction profiles.