Open AccessLack of Atorvastatin Effect on Monocyte Gene Expression and Inflammatory Markers in HIV-1- infected ART-suppressed Individuals at Risk of non-AIDS Comorbidities
Author(s) -
Anjana Yadav,
Andrew V. Kossenkov,
Louise C. Showe,
Sarah J. Ratcliffe,
Grace Choi,
Luis J. Montaner,
Pablo Tebas,
Pamela A. Shaw,
Ronald G. Collman
Publication year - 2021
Publication title -
pathogens and immunity
Language(s) - English
Resource type - Journals
ISSN - 2469-2964
DOI - 10.20411/pai.v6i2.461
Subject(s) - cd14 , atorvastatin , monocyte , medicine , ccr2 , cd16 , immunology , cd163 , ccl2 , inflammation , flow cytometry , chemokine , biology , macrophage , immune system , in vitro , cd8 , biochemistry , cd3 , chemokine receptor
Many people living with HIV have persistent monocyte activation despite viral suppression by antiretroviral therapy (ART), which contributes to non-AIDS complications including neurocognitive and other disorders. Statins have immunomodulatory properties that might be beneficial by reducing monocyte activation.