Generation of a Novel SARS-CoV-2 Sub-genomic RNA Due to the R203K/G204R Variant in Nucleocapsid: Homologous Recombination has Potential to Change SARS-CoV-2 at Both Protein and RNA Level | Zendy

Shay Leary | Zendy; Silvana Gaudieri | Zendy; Matthew Parker | Zendy; Abha Chopra | Zendy; Ian James | Zendy; Suman Pakala | Zendy; Eric Alves | Zendy; Mina John | Zendy; Benjamin B. Lindsey | Zendy; Alexander J. Keeley | Zendy; Sarah Rowland–Jones | Zendy; Maurice S. Swanson | Zendy; David A. Ostrov | Zendy; Jodi L. Bubenik | Zendy; Suman R. Das | Zendy; John Sidney | Zendy; Alessandro Sette | Zendy; Thushan I. de Silva | Zendy; Elizabeth Phillips | Zendy; S. Mallal | Zendy

Open Access

Generation of a Novel SARS-CoV-2 Sub-genomic RNA Due to the R203K/G204R Variant in Nucleocapsid: Homologous Recombination has Potential to Change SARS-CoV-2 at Both Protein and RNA Level

Author(s) -

Shay Leary,

Silvana Gaudieri,

Matthew Parker,

Abha Chopra,

Ian James,

Suman Pakala,

Eric Alves,

Mina John,

Benjamin B. Lindsey,

Alexander J. Keeley,

Sarah Rowland–Jones,

Maurice S. Swanson,

David A. Ostrov,

Jodi L. Bubenik,

Suman R. Das,

John Sidney,

Alessandro Sette,

Thushan I. de Silva,

Elizabeth Phillips,

S. Mallal

Publication year - 2021

Publication title -

pathogens and immunity

Language(s) - English

Resource type - Journals

ISSN - 2469-2964

DOI - 10.20411/pai.v6i2.460

Subject(s) - rna , covid-19 , virology , recombination , sars virus , homologous recombination , biology , genetics , dna , gene , medicine , disease , pathology , infectious disease (medical specialty)

Genetic variations across the SARS-CoV-2 genome may influence transmissibility of the virus and the host's anti-viral immune response, in turn affecting the frequency of variants over time. In this study, we examined the adjacent amino acid polymorphisms in the nucleocapsid (R203K/G204R) of SARS-CoV-2 that arose on the background of the spike D614G change and describe how strains harboring these changes became dominant circulating strains globally.

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