Open AccessGeneration of a Novel SARS-CoV-2 Sub-genomic RNA Due to the R203K/G204R Variant in Nucleocapsid: Homologous Recombination has Potential to Change SARS-CoV-2 at Both Protein and RNA Level
Author(s) -
Shay Leary,
Silvana Gaudieri,
Matthew Parker,
Abha Chopra,
Ian James,
Suman Pakala,
Eric Alves,
Mina John,
Benjamin B. Lindsey,
Alexander J. Keeley,
Sarah RowlandJones,
Maurice S. Swanson,
David A. Ostrov,
Jodi L. Bubenik,
Suman Das,
John Sidney,
Alessandro Sette,
Thushan I. de Silva,
Elizabeth Phillips,
S. Mallal,
Covid Genomics Uk
Publication year - 2021
Publication title -
pathogens and immunity
Language(s) - English
Resource type - Journals
ISSN - 2469-2964
DOI - 10.20411/pai.v6i2.460
Subject(s) - biology , rna , genetics , genome , homologous recombination , gene , virology
Genetic variations across the SARS-CoV-2 genome may influence transmissibility of the virus and the host's anti-viral immune response, in turn affecting the frequency of variants over time. In this study, we examined the adjacent amino acid polymorphisms in the nucleocapsid (R203K/G204R) of SARS-CoV-2 that arose on the background of the spike D614G change and describe how strains harboring these changes became dominant circulating strains globally.