Open AccessAlpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2–Priming Protease TMPRSS2
Author(s) -
Nurit P. Azouz,
Andrea M. Klingler,
Victoria Callahan,
Ivan Akhrymuk,
Katarina Elez,
Lluís Raich,
Brandon Michael Henry,
Justin L. Benoit,
Stefanie W. Benoit,
Frank Noé,
Kylene Kehn-Hall,
Marc E. Rothenberg
Publication year - 2021
Publication title -
pathogens and immunity
Language(s) - English
Resource type - Journals
ISSN - 2469-2964
DOI - 10.20411/pai.v6i1.408
Subject(s) - proteases , tmprss2 , serine protease , protease inhibitor (pharmacology) , protease , serpin , extracellular , biology , biochemistry , chemistry , virology , enzyme , virus , covid-19 , viral load , medicine , gene , disease , pathology , antiretroviral therapy , infectious disease (medical specialty)
Host proteases have been suggested to be crucial for dissemination of MERS, SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution of membrane versus intracellular proteases remains controversial. Transmembrane serine protease 2 (TMPRSS2) is regarded as one of the main proteases implicated in the coronavirus S protein priming, an important step for binding of the S protein to the angiotensin-converting enzyme 2 (ACE2) receptor before cell entry.