Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2–Priming Protease TMPRSS2 | Zendy

Nurit P. Azouz | Zendy; Andrea M. Klingler | Zendy; Victoria Callahan | Zendy; Ivan Akhrymuk | Zendy; Katarina Elez | Zendy; Lluı́s Raich | Zendy; Brandon Michael Henry | Zendy; Justin L. Benoit | Zendy; Stefanie W. Benoit | Zendy; Frank Noé | Zendy; Kylene KehnHall | Zendy; Marc E. Rothenberg | Zendy

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Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2–Priming Protease TMPRSS2

Author(s) -

Nurit P. Azouz,

Andrea M. Klingler,

Victoria Callahan,

Ivan Akhrymuk,

Katarina Elez,

Lluı́s Raich,

Brandon Michael Henry,

Justin L. Benoit,

Stefanie W. Benoit,

Frank Noé,

Kylene KehnHall,

Marc E. Rothenberg

Publication year - 2021

Publication title -

pathogens and immunity

Language(s) - English

Resource type - Journals

ISSN - 2469-2964

DOI - 10.20411/pai.v6i1.408

Subject(s) - tmprss2 , protease inhibitor (pharmacology) , virology , protease , covid-19 , biology , microbiology and biotechnology , medicine , virus , enzyme , biochemistry , viral load , pathology , infectious disease (medical specialty) , disease , antiretroviral therapy , outbreak

Host proteases have been suggested to be crucial for dissemination of MERS, SARS-CoV, and SARS-CoV-2 coronaviruses, but the relative contribution of membrane versus intracellular proteases remains controversial. Transmembrane serine protease 2 (TMPRSS2) is regarded as one of the main proteases implicated in the coronavirus S protein priming, an important step for binding of the S protein to the angiotensin-converting enzyme 2 (ACE2) receptor before cell entry.

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