CD161 Expression on Mucosa-Associated Invariant T Cells is Reduced in HIV-Infected Subjects Undergoing Antiretroviral Therapy Who Do Not Recover CD4+ T Cells | Zendy

Michael L. Freeman | Zendy; Stephen R. Morris | Zendy; Michael M. Lederman | Zendy

Open Access

CD161 Expression on Mucosa-Associated Invariant T Cells is Reduced in HIV-Infected Subjects Undergoing Antiretroviral Therapy Who Do Not Recover CD4+ T Cells

Author(s) -

Michael L. Freeman,

Stephen R. Morris,

Michael M. Lederman

Publication year - 2017

Publication title -

pathogens and immunity

Language(s) - English

Resource type - Journals

ISSN - 2469-2964

DOI - 10.20411/pai.v2i3.136

Subject(s) - immune system , immunology , cd8 , peripheral blood mononuclear cell , biology , t cell , cytotoxic t cell , t cell receptor , cytokine , flow cytometry , in vitro , biochemistry

Mucosa-associated invariant T (MAIT) cells are a recently identified class of innate-like T cells that are involved in the mucosal immune response. MAIT cells are characterized by expression of TCR Vα7.2 and CD161. In HIV infection, there is a profound early loss of MAIT cells from the circulation that never fully recovers, even after prolonged viral control with antiretroviral therapy (ART).

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