Open AccessCD161 Expression on Mucosa-Associated Invariant T Cells is Reduced in HIV-Infected Subjects Undergoing Antiretroviral Therapy Who Do Not Recover CD4+ T Cells
Author(s) -
Michael Freeman,
Sherri J. Morris,
Michael M. Lederman
Publication year - 2017
Publication title -
pathogens and immunity
Language(s) - English
Resource type - Journals
ISSN - 2469-2964
DOI - 10.20411/pai.v2i3.136
Subject(s) - immune system , cd8 , immunology , peripheral blood mononuclear cell , biology , t cell receptor , t cell , cytotoxic t cell , cytokine , flow cytometry , in vitro , biochemistry
Mucosa-associated invariant T (MAIT) cells are a recently identified class of innate-like T cells that are involved in the mucosal immune response. MAIT cells are characterized by expression of TCR Vα7.2 and CD161. In HIV infection, there is a profound early loss of MAIT cells from the circulation that never fully recovers, even after prolonged viral control with antiretroviral therapy (ART).