Open AccessIntimate Partner Violence is Associated with Increased CD4+ T-Cell Activation Among HIV-Negative High-Risk Women
Author(s) -
Ameeta S. Kalokhe,
Chris Ibegbu,
Surinder Kaur,
Rama Rao Amara,
Mary E. Kelley,
Carlos del Rı́o,
Rob Stephenson
Publication year - 2016
Publication title -
pathogens and immunity
Language(s) - English
Resource type - Journals
ISSN - 2469-2964
DOI - 10.20411/pai.v1i1.120
Subject(s) - domestic violence , medicine , immune system , cd38 , foxp3 , immunology , poison control , injury prevention , biology , genetics , environmental health , stem cell , cd34
Biological pathways mediating the link between intimate partner violence (IPV) and increased HIV risk remain unexplored. We hypothesized that IPV-induced stress negatively affects HIV systemic immune defenses and aimed to evaluate whether IPV was associated with immune profiles linked to HIV susceptibility: CD4 activation and diminished regulatory T-cell (Treg) frequency.