Open AccessCongenital megacolon
Author(s) -
Caroline Judeikis,
Joaquim Murray BustorffSilva,
Márcia Alessandra Cavalaro Pereira da Silva
Publication year - 2018
Publication title -
revista dos trabalhos de iniciação científica da unicamp
Language(s) - English
Resource type - Journals
ISSN - 2596-1969
DOI - 10.20396/revpibic262018297
Subject(s) - medicine , megacolon , disease , gold standard (test) , ablation , benzalkonium chloride , surgery , pathology
Hirschsprung's disease is characterized by colonic aganglionosis, affecting mainly newborns. The current treatment of this pathology is surgical, but several studies are underway to develop less invasive methods that could cause less comorbidities. These studies use congenital megacolon models, one of which uses benzalkonium chloride to cause neurogenic ablation. The objective of this study is to demonstrate the effectiveness of aganglionosis provided by this drug by describing the remaining cells after denervation in order to optimize studies that use this model later.