Open AccessInfluence of rs6667202 SNP on Interleukin-10 levels in the gingival fluid of patients with periodontitis grade C
Author(s) -
Camila Schmidt Stolf,
Tiago Taiete,
Márcio Zaffalon Casati,
Enílson Antônio Sallum,
Francisco Humberto Nociti,
Karina Gonzáles Silvério,
Renato Corrêa Viana Casarin
Publication year - 2021
Publication title -
brazilian journal of oral sciences/brazilian journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 11
eISSN - 1677-3225
pISSN - 1677-3217
DOI - 10.20396/bjos.v20i00.8661654
Subject(s) - snp , single nucleotide polymorphism , periodontitis , genotype , bleeding on probing , interleukin 10 , medicine , gastroenterology , polymorphism (computer science) , dentistry , biology , cytokine , genetics , gene
Grade C periodontitis in youngers is characterized by a severe form of periodontitis, and IL10 rs6667202 single nucleotide polymorphism (SNP) has been described as an important feature in this disease etiology. Aim: This study aimed to evaluate, in vivo, the functionality of IL10 rs6667202 SNP on IL-10 gingival fluid levels. Methods: Thirty patients with Perio4C were selected, 15 with the IL10 AA genotype (rs6667202) and 15 with AC/CC genotypes. The gingival fluid was collected from two sites with probing depth ≥ 7 mm and bleeding on probing, and two healthy sites. The IL-10 concentration was determined by Luminex/MAGpix platform. Results: In deep pockets, the IL10 AA genotype presented a lower concentration of IL-10 when compared with AC or CC genotypes (p 0.05). Conclusion: IL10 rs6667202 SNP decreases the production of IL-10 in crevicular fluid, potentially affecting this disease progression.