Open AccessProfiling of pro-inflammatory cytokines in radiation induced oral mucositis (riom) among indian patients
Author(s) -
Moshahid Alam Rizvi,
Akanksha Marwah,
Zaffar Iqbal,
Md. Zafaryab,
Mahesh Verma,
Sunita Gupta
Publication year - 2017
Publication title -
brazilian journal of oral sciences/brazilian journal of oral sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 11
eISSN - 1677-3225
pISSN - 1677-3217
DOI - 10.20396/bjos.v15i4.8650040
Subject(s) - mucositis , medicine , pathogenesis , gastroenterology , tumor necrosis factor alpha , interleukin 6 , radiation therapy , proinflammatory cytokine , chemotherapy , interleukin , immunology , inflammation , cytokine
Radiation-induced oral mucositis (RIOM) is aimed at evaluating the expression of NF-κβ, IL-1α, IL-6, IL-8 and TNF-α in patients with RIOM so as to validate their role in the pathobiology of the disease. Blood samples were collected and serum of 45 patients isolated with clinical signs and symptoms of mucositis and 10 healthy controls were also included in the study. The expression level of NF-κβ, IL-1α, IL-6, IL-8, TNF-α was investigated using ELISA. Mann Whitney U test was applied to find the significance of the expression of these markers in RIOM patients as compared to normal healthy controls and significant expression (P 0.05) IL-1α and IL-8 was found. No significant change in the expression level of the cytokines was observed for patients undergoing chemotherapy and radiation therapy as well as those receiving only the radiation therapy as a part of their treatment. We have also found less expression in grade 1 of mucositis as compared to grade 4. Pro- inflammatory cytokines indeed play a vital role in the pathogenesis as well as progression of RIOM.