Open AccessPolissacarídeo de Escherichia coli na Prevenção da Infeção do Trato Urinário Recorrente: Uma Revisão Baseada na Evidência
Author(s) -
Manuel Tinoco,
M.V.O. Dos Santos,
Conceição Reitor,
A Fernando Rodrigues,
João M. Monteiro
Publication year - 2018
Publication title -
acta médica portuguesa
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.316
H-Index - 21
eISSN - 1646-0758
pISSN - 0870-399X
DOI - 10.20344/amp.9367
Subject(s) - escherichia coli , chemistry , medicine , biochemistry , gene
Recurrent urinary tract infection is frequent and it is related to morbidity, costs and growing antibiotic resistance. OM 8930 vaccine is composed by Escherichia coli polysaccharide and it is a possible prophylactic measure, but there is doubt as to its effectiveness.Material and Methods: We performed a systematic review in evidence-based medicine databases with rigorous bibliography selection.Results: We found an effective decrease of recurrences in test groups.Discussion: We recommend the administration of the vaccine as prophylaxis of recurrent cystitis.Conclusion: The vaccine has impact on the recurrent cystitis relapse rate. We suggest that more studies be carried out to evaluate the vaccine cost-benefit and its effectiveness in complicated urinary infections.