Open AccessPrimary results of replacement the experimental hyaline cartilage defect with human fibroblast cell culture
Author(s) -
Mikhail S. Bozhokin,
D. M. Marchenko,
E. R. Mikhailova,
A.P. Antipov,
Yu. A. Nashchekina,
D. B. Vcherashnij,
Sergey Bondarev,
В. Н. Круглов
Publication year - 2022
Publication title -
vestnik medicinskogo instituta «reaviz». reabilitaciâ, vrač i zdorovʹe/vestnik medicinskogo instituta "reaviz". reabilitaciâ, vrač i zdorovʹe
Language(s) - English
Resource type - Journals
eISSN - 2782-1579
pISSN - 2226-762X
DOI - 10.20340/vmi-rvz.2022.2.morph.1
Subject(s) - scaffold , hyaline cartilage , cartilage , fibroblast , regeneration (biology) , tec , dermal fibroblast , cell culture , microbiology and biotechnology , biomedical engineering , hyaline , cell , anatomy , materials science , chemistry , biology , pathology , medicine , physics , articular cartilage , biochemistry , ionosphere , genetics , alternative medicine , astronomy , osteoarthritis
The hyaline cartilage damage problem is actual, but existing recovery methods are not fully sufficient. A promising solution of this problem can be the implantation of a tissue-engineered structure (TEC), consisting of a cell culture and a biodegradable scaffold. In this experiment we created a construct consisting of a polylactide scaffold and a human dermal fibroblasts culture. After implantation of TEC in the modeled defect area we analyzed the experimental group regeneration results in comparison to the control group.