Primary results of replacement the experimental hyaline cartilage defect with human fibroblast cell culture | Zendy

M. S. Bozhokin | Zendy; Daria M. Marchenko | Zendy; Elena Mikhailova | Zendy; Alexander P. Antipov | Zendy; Yu. A. Nashchekina | Zendy; D. B. Vcherashnij | Zendy; S. V. Novoseltsev | Zendy; В. Н. Круглов | Zendy

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Primary results of replacement the experimental hyaline cartilage defect with human fibroblast cell culture

Author(s) -

M. S. Bozhokin,

Daria M. Marchenko,

Elena Mikhailova,

Alexander P. Antipov,

Yu. A. Nashchekina,

D. B. Vcherashnij,

S. V. Novoseltsev,

В. Н. Круглов

Publication year - 2022

Publication title -

bulletin of the medical institute reaviz (rehabilitation doctor and health)

Language(s) - English

Resource type - Journals

eISSN - 2782-1579

pISSN - 2226-762X

DOI - 10.20340/vmi-rvz.2022.2.morph.1

Subject(s) - scaffold , hyaline cartilage , cartilage , fibroblast , regeneration (biology) , tec , dermal fibroblast , cell culture , microbiology and biotechnology , biomedical engineering , hyaline , cell , anatomy , materials science , chemistry , biology , pathology , medicine , physics , articular cartilage , biochemistry , ionosphere , genetics , alternative medicine , astronomy , osteoarthritis

The hyaline cartilage damage problem is actual, but existing recovery methods are not fully sufficient. A promising solution of this problem can be the implantation of a tissue-engineered structure (TEC), consisting of a cell culture and a biodegradable scaffold. In this experiment we created a construct consisting of a polylactide scaffold and a human dermal fibroblasts culture. After implantation of TEC in the modeled defect area we analyzed the experimental group regeneration results in comparison to the control group.

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