Open AccessOn the issue of telocytes of skin
Author(s) -
А. Ю. Цибулевский
Publication year - 2020
Publication title -
vestnik medicinskogo instituta «reaviz». reabilitaciâ, vrač i zdorovʹe/vestnik medicinskogo instituta "reaviz". reabilitaciâ, vrač i zdorovʹe
Language(s) - English
Resource type - Journals
eISSN - 2782-1579
pISSN - 2226-762X
DOI - 10.20340/vmi-rvz.2020.4.15
Subject(s) - immunostaining , cytoplasm , colocalization , dermis , pathology , biology , microbiology and biotechnology , population , immunohistochemistry , anatomy , medicine , environmental health
This manuscript is devoted to the description of a new population of interstitial cells – telocytes discovered by L.M. Popescu and M.S. Faussone-Pellegrini. Later telocytes were found in the dermis, where they perform an important metabolic function and maintain homeostasis. Telocytes are small cells with a large elongated nucleus and a small amount of cytoplasm, which contains long cellular prolongations made of thin (podomeres, 40–100 nm) and thick (pods, 200–500 nm) segments – telopodes. Based on the results of morphological studies, it was possible to reliably differentiate telocytes from fibroblasts. During immunostaining they express CD34 and PDGFRα. Nevertheless, despite the numerous studies carried out regarding the role of telocytes, their function in the skin remains unclear and requires further investigations.