Open AccessMORPHOFUNCTIONAL CHARACTERISTICS OF TESTES IN WHITE RATS TREATED WITH BISPHENOL A AND TRICLOSAN
Author(s) -
С. В. Чигринец,
G. V. Bryuhin,
S. N. Zavyalov
Publication year - 2018
Publication title -
morfologičeskie vedomosti
Language(s) - English
Resource type - Journals
eISSN - 2686-8741
pISSN - 1812-3171
DOI - 10.20340/mv-mn.18(26).04.32-34
Subject(s) - triclosan , bisphenol a , endocrine system , medicine , endocrinology , bisphenol , sperm , chemistry , epithelium , andrology , biology , hormone , pathology , genetics , organic chemistry , epoxy
We studied the effect of unstable ubiquitous endocrine disrupters bisphenol A (BPA) and triclosan (TCS) on the reproductive function of adult male Wistar rats. BPA and TCS concentrations were measured directly in testicular tissue by gas chromatography with mass spectrometry (GC-MS). Comparison groups were found to be statistically significantly different in the concentrations of bisphenol A and triclosan in testicular tissues. The study showed that bisphenol A and triclosan have a negative effect on the morphofunctional state of the male reproductive glands of sexually mature rats, causing a decrease in testicular mass, a decrease in parenchyma, the number and diameter of the seminiferous tubules, an increase in the number of convoluted seminiferous tubules with desquamated epithelium, and a decrease in sperm cells on the background of an increase in their atypical forms.