Open AccessFeatures of cytokine balance in patients with osteoarthrosis and atherosclerosis
Author(s) -
С. М. Цвингер,
А В Говорин,
А. М. Караченова
Publication year - 2020
Publication title -
sibirskoe medicinskoe obozrenie
Language(s) - English
Resource type - Journals
eISSN - 2500-0136
pISSN - 1819-9496
DOI - 10.20333/2500136-2020-6-70-74
Subject(s) - osteoarthritis , medicine , cytokine , inflammation , proinflammatory cytokine , balance (ability) , intima media thickness , subclinical infection , tumor necrosis factor alpha , pathology , physical therapy , carotid arteries , alternative medicine
The aim of the research is to study the content of some key pro / anti-inflammatory cytokines in patients with osteoarthritis and to evaluate their role in predicting atherogenesis in this category of patients. Material and methods. Patients with primary osteoarthritis of I-III radiological stages were examined. Doppler vessels ultrasound (Doppler ultrasound) of the neck, upper and lower extremities was performed; blood levels of pro / anti-inflammatory cytokines were examined: IL-1β, TNF-α, IL-6, IL- 8, IL-18, MCP-1, IL-17, IL-10, IL-33 by flow cytometry. Results. According to the thickness of intima - media complex, the patients were divided into 2 groups: with a normal thickness of intima - media complex and with atherosclerotic plaque. A significant increase in pro-inflammatory cytokines was revealed in patients with osteoarthritis associated with atherosclerosis compared with those having osteoarthritis with normal thickness of intima-media complex. The level of pro / anti-inflammatory cytokines along with atherosclerosis are closely interconnected. Conclusion. According to the results of the studies obtained, it was found that a long-term subclinical inflammatory process leads to multidirectional disturbances in cytokine balance in patients with osteoarthritis, which probably contributes to the progression of both osteoarthritis and atherosclerosis. A possible factor of early atherosclerosis development in patients with osteoarthritis was also identified.