Open AccessPharmacokinetics and pharmacogenetics of edoxaban
Author(s) -
А. В. Савинова,
М. М. Петрова,
Natalia A. Shnayder,
Е. Н. Бочанова,
Р. Ф. Насырова,
N.Y. Shimokhina
Publication year - 2020
Publication title -
sibirskoe medicinskoe obozrenie
Language(s) - English
Resource type - Journals
eISSN - 2500-0136
pISSN - 1819-9496
DOI - 10.20333/2500136-2020-6-26-35
Subject(s) - edoxaban , slco1b1 , medicine , pharmacokinetics , pharmacogenetics , pharmacology , cyp2c9 , cyp3a4 , warfarin , bioinformatics , atrial fibrillation , gene , rivaroxaban , genetics , biology , cytochrome p450 , metabolism , genotype
Edoxaban is a new generation of oral anticoagulant; it is selective, direct and reversible inhibitor of activated blood coagulation factor X (F Xa), serine protease responsible for thrombin formation. Edoxaban is used to prevent stroke in non-valvular atrial fibrillation, to treat deep vein thrombosis and pulmonary embolism. The purpose of the review is to analyze the associative studies of OHB of CYP3A4 / 5 and ABCB1 genes, as well as to search for new candidate genes reflecting the efficacy and safety of edoxaban. The search for full-text publications in Russian and English over the past two decades was carried out in eLibrary, PubMed, Web of Science, OMIM databases using the following keywords: edoxaban, pharmacokinetics, pharmacogenetics, efficacy, and safety. The review covers pharmacokinetics of edoxaban, as well as pharmacogenetic features of the drug metabolism in details. Candidate genes influencing concentration of edoxaban are genes encoding key enzymes of its metabolism – CES1, CYP3A4 / 5, ABCB1, and, to a lesser extent, SLCO1B1. By present day, numerous NVS of candidate genes have been identified. They potentially affect pharmacokinetics of edoxaban, but their role in real clinical practice requires further study