Open AccessImmunopathological mechanisms in sepsis of viral etiology in COVID-19
Author(s) -
А.М. Зиганшин,
AUTHOR_ID,
A.R. Mulyukov,
AUTHOR_ID
Publication year - 2021
Publication title -
sibirskoe medicinskoe obozrenie
Language(s) - English
Resource type - Journals
eISSN - 2500-0136
pISSN - 1819-9496
DOI - 10.20333/25000136-2021-6-35-43
Subject(s) - immune system , sepsis , immunology , pathogen , organism , immunopathology , pathological , biology , etiology , inflammation , receptor , medicine , pathology , genetics
The article provides information on immunopathology in sepsis and the commonality between immunopathogenetic processes of sepsis and the new coronavirus infection (COVID-19). As a result of the inability of the immune system to cope with aggression of the pathogen, inadequate immune activity occurs manifested by the systemic inflammatory response syndrome, resulting in damage to tissues of the host organism. In response, compensatory antiinflammatory response syndrome is activated, which is manifested by inhibition of the immune response. One of its main mechanisms is signals produced by membrane receptors and their ligands. Against the background of inability of the host organism to neutralise the pathogen, numerous pathological phenomena and complications occur leading to damage to human tissues.