Open AccessMolecular and genetic predictors of endothelial dysfunction and impairment of angioand neurogenesis in the perinatal period (a literature review)
Author(s) -
S. B. Berezhanskaya,
Е. А. Лукьянова,
M.K. Abduragimova
Publication year - 2021
Publication title -
sibirskoe medicinskoe obozrenie
Language(s) - English
Resource type - Journals
eISSN - 2500-0136
pISSN - 1819-9496
DOI - 10.20333/25000136-2021-5-14-23
Subject(s) - neurogenesis , perinatal period , neuroscience , medicine , period (music) , endothelial dysfunction , genetic predisposition , fetus , pregnancy , bioinformatics , pathology , biology , disease , genetics , physics , acoustics
Perinatal pathologies serve as the basis for a great variety of diseases in teenagers and adults including the especially frequent and important diseases of the nervous system which is vulnerable during the period of ante- and early postnatal development, especially against the background of genetic predisposition to it. This leads to development of pathology also manifesting at later stages of life. In this connection, the review presents molecular and genetic predictors of endothelial dysfunction and impairment of angio- and neurogenesis during the perinatal period. The article presents facts related to the influence of endothelial dysfunction as a trigger for pregnancy pathology and fetal-programmed diseases. A discussion regarding the contribution made by the congenital and by the acquired into basic mechanisms of fetal development including the brain and its pathologies