Open AccessDrug-induced acute pancreatitis: pathogenetic mechanisms
Author(s) -
О Д Остроумова,
E.S. Akimovа,
А. И. Кочетков
Publication year - 2021
Publication title -
sibirskoe medicinskoe obozrenie
Language(s) - English
Resource type - Journals
eISSN - 2500-0136
pISSN - 1819-9496
DOI - 10.20333/25000136-2021-3-35-43
Subject(s) - medicine , acute pancreatitis , pancreatitis , drug , pancreas , disease , drug development , immune system , intensive care medicine , bioinformatics , pharmacology , immunology , biology
Drug-induced (DI) acute pancreatitis (AP) is a difficultly diagnosed disease amounting to 2% among all AP cases that may lead to development of life-threatening complications. This article considers potentially hazardous medicinal products as well as the most significant variants of the pancreas: structural and functional impairment of the pancreatic duct, direct cytotoxic effects, metabolic disorders, vascular disorders, immune-mediated damage to the pancreas and hypersensitivity. The review was performed based on the publications present in the E-library and PubMed databases dated 1965-2020. Due to regular publication of reports on potential associations between specific medicinal products and AP development, medical practitioners must be informed about the potentially hazardous drugs and mechanisms of DI AP development.