Open AccessThe use of prosthetic groups for synthesis of addressed RFLP molecules for positron emission tomography
Author(s) -
A.V. Ozerskay,
Кirill V. Belugin,
Oleg N. Badmaev,
Federal Siberian Scientific,
Biological Agency
Publication year - 2021
Publication title -
sibirskoe medicinskoe obozrenie
Language(s) - English
Resource type - Journals
eISSN - 2500-0136
pISSN - 1819-9496
DOI - 10.20333/25000136-2021-2-84-86
Subject(s) - peptide , peptide synthesis , chemistry , combinatorial chemistry , positron emission tomography , biochemistry , nuclear medicine , medicine
The aim of the research. An intensive research is underway to create new methods for the synthesis of fl uorine-18 labeled radiopharmaceuticals. Th e aim of this work is to select iodoaliphatic carboxylic acids and esters for radiopharmaceuticals labeling. Material and methods. A simple way to obtain z-yodalifi c carbonic acids and complex esters from commercially available cyclic ketones has been developed. Automatic synthesis of 18F-fl uoroproprostatic groups and 18F fl uoride peptide agents is successfully carried out using new original materials and various purifi cation methods with solid phase cartridges Results. In further work, it is planned to use diff erent 18F-fl uoroproproprostatic groups for synthesis with various peptide agents. Conclusion. Based on these compounds 18F-fl uoroproproprostatic groups were synthesized. Octreotid as an analogue of somatostatin, the non-immunoglobulin-specifi c frame proteins (designed ankyrin repeat proteins) for targeted imaging of tumor cells hyperexpressing Her-2/neu, and prostate-specifi c membrane antigen (PSMA) inhibitor are signifi cant peptide agents.