Open AccessCyclodextrins - Fields of Application. Part II
Author(s) -
Gheorghe Duca,
A. Ivancic,
V. Boldescu
Publication year - 2012
Publication title -
chemistry journal of moldova
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.275
H-Index - 5
eISSN - 2345-1688
pISSN - 1857-1727
DOI - 10.19261/cjm.2012.07(2).15
Subject(s) - chemistry , combinatorial chemistry , cyclodextrin , biological activity , endogeny , macromolecule , membrane , organic chemistry , biochemistry , in vitro
This paper represents an analysis of potential and current applications of cyclodextrins as biologically active substances in medicine. The main applications described here include use of cyclodextrins as agents that form inclusion complexes with endogenous substances (membrane lipids, cellular cholesterol), agents that form inclusion complexes with exogenous substances with their man role as guest molecules (sugammadex, FBCx), agents that block endogenous and exogenous macromolecules (ion channels, anthrax toxin, α-hemolysin), and agents which activity is based on the chemical nature of them and of their derivatives (cyclodextrin polysulphate derivatives). The fi rst classifi cation for medically important biological activity of cyclodextrins has been proposed.