Spectrophotometric Studies of Sanguinarine-Β-Cyclodextrin Complex Formation | Zendy

Veaceslav Boldescu | Zendy; Irina Kacsó | Zendy; Ioan Bratub | Zendy; Gheorghe Duca | Zendy

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Spectrophotometric Studies of Sanguinarine-Β-Cyclodextrin Complex Formation

Author(s) -

Veaceslav Boldescu,

Irina Kacsó,

Ioan Bratub,

Gheorghe Duca

Publication year - 2008

Publication title -

chemistry journal of moldova

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.275

H-Index - 5

eISSN - 2345-1688

pISSN - 1857-1727

DOI - 10.19261/cjm.2008.03(1).18

Subject(s) - chemistry , polyvinylpyrrolidone , sanguinarine , cyclodextrin , complex formation , hyperchromicity , polymer , nuclear chemistry , inorganic chemistry , stereochemistry , polymer chemistry , chromatography , organic chemistry , biochemistry , alkaloid , dna

The main aim of this study was to investigate the influence of pH and the presence of hydrophilic polymer polyvinylpyrrolidone on the formation of sanguinarine-β-cyclodextrin (SANG-β-CD) inclusion complex. Spectrophotometric studies of the SANG-β-CD systems in the presence and without 0.1 % PVP at the pH 5.0 did not show any evidence of the complex formation. However, the same systems showed several obvious evidences at the pH 8.0: the hyperchromic and the hypochromic effects and the presence of the isosbestic point in the region of 200 – 210 nm. The association constants calculated by three linear methods: Benesi-Hildebrand, Scott and Scatchard, were two times higher for the systems with addition of 0.1% PVP than for the systems without it.

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