Open AccessSteroidal Glycosides from the Seeds of Hyoscyamus Niger L. and their Antifungal Activity
Author(s) -
Irina Lunga,
Pavel Chintea,
S. A. Shvets,
Anna Favelb,
Cosimo Pìzza
Publication year - 2007
Publication title -
chemistry journal of moldova
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.275
H-Index - 5
eISSN - 2345-1688
pISSN - 1857-1727
DOI - 10.19261/cjm.2007.02(1).05
Subject(s) - phytochemical , glycoside , chemistry , antifungal , terpene , traditional medicine , botany , chromatography , stereochemistry , biochemistry , microbiology and biotechnology , biology , medicine
Phytochemical analysis of the seeds of Hyocyamus niger L. (Solonaceae) resulted in the isolation of six steroidal glycosides, two furostanol (1, 2) and four spirostanol saponins (3, 4, 5, 6), which were found in this plant for the first time. The structures of these compounds were determined by detailed analysis of their spectral data, including two-dimensional NMR spectroscopy and MS spectroscopy. The antifungal activity of a crude steroidal glycoside extract, fractions of spirostanoles and individual glicosides was investigated in vitro against a panel of human pathogenic fungi, yeasts as well as dermatophytes and filamentous species.