Open AccessDiagram Fase dan Sifat Termodinamik Campuran Biner Ketoprofen-Asam Suksinat
Author(s) -
Yudi Wicaksono,
Dwi Setyawan,
S. Siswandono
Publication year - 2018
Publication title -
jurnal ilmu dasar
Language(s) - English
Resource type - Journals
ISSN - 2442-5613
DOI - 10.19184/jid.v19i2.5521
Subject(s) - eutectic system , phase diagram , differential scanning calorimetry , ketoprofen , succinic acid , materials science , thermodynamics , binary system , calphad , phase (matter) , chemistry , chromatography , organic chemistry , binary number , microstructure , composite material , mathematics , physics , arithmetic
The equilibrium phase diagram and thermodynamic properties of a mixture of drugs and additives are information related to various possible interaction processes between components. Therefore, we conducted a study of the phase diagrams and thermodynamic properties of binary mixtures of ketoprofen-succinic acid to estimate the types of interactions that may occur between these materials. The solid-liquid phase diagram of ketoprofen-succinic acid binary mixtures was determined by differential scanning calorimetry and composition of eutectic system was determined accurately using a Tamman diagram. The measurement of binary mixtures of ketoprofen-succinic acid with differential scanning calorimeter obtained the value of melting temperature and heat of fusion of ketoprofen- succinic acid system. The solid-liquid phase diagram of ketoprofen- succinic acid showed the formation of eutectic type phase diagram. The Tamman diagram showed accurately composition of the eutectic system of the Kp-SA binary mixtures at the mole fraction of Kp 0.87 and temperature 96.9oC.Keywords: ketoprofen, phase diagram, eutectic system, Tamman diagram