Open AccessOptimization of Reactions Opening Cyclic Ring of Pentose Sugar Derivatives through Dithioacetalisation Reactions
Author(s) -
Nuriman Nuriman
Publication year - 2017
Publication title -
jurnal ilmu dasar
Language(s) - English
Resource type - Journals
ISSN - 2442-5613
DOI - 10.19184/jid.v17i2.2686
Subject(s) - pentose , chemistry , solvent , xylose , sugar , hexane , organic chemistry , ring (chemistry) , reaction conditions , catalysis , fermentation
Ring-opening reaction of cyclic pentose sugar derivatives of 2,3,4-Tri-O-benzyl- D-xylopyranoseto derivatives of acyclic 2,3,4-Tri-O-benzyl-D-xylose-Dipropyl dithioacetal been done andoptimized. The reaction was performed using a precursor propanathiol with concentrated HCl.Optimization of reaction conditions was conducted by varying propanathiol concentration,reaction time and optimization of the reaction temperature which the product ioslation conductedusing a variety of solvents. The results of this reaction was obtained 2,3,4-Tri-O-benzyl- Dxylose-Dipropyl dithioacetal with the highest randemen (97%), better than the previous reactionthrough propanathiol excessive concentration, reaction time of 2 hours and the temperature of thereaction at room temperature. Product Isolations using solvent dikloromathane more effectivethan the use of other organic solvents. Purification of reaction products is done through a columnchromatography using a solvent mixture of 20% ethyl acetate-hexane.Keywords: Optimization, Cyclic Ring, Dithioasetalisasi