Open AccessCUMULATIVE PROPERTIES OF THE NEW ANTI-MIGENOUS COMPOUND IN THE TABLET MEDICAL FORM
Author(s) -
В. И. Корнилов,
D. S. Yakovlev,
В. В. Багметова,
Л. И. Бугаева,
А. А. Спасов,
A.Yu. Getmamenko
Publication year - 2020
Publication title -
vestnik volgogradskogo gosudarstvennogo medicinskogo universiteta
Language(s) - English
Resource type - Journals
eISSN - 1994-9499
pISSN - 1994-9480
DOI - 10.19163/1994-9480-2020-4(76)-46-49
Subject(s) - cumulative dose , dosage form , derivative (finance) , medicine , pharmacology , financial economics , economics
Cumulative properties of 2-metoxifenil-imidazobenzimidazole derivative (RU-31) in tablet medical form (8 mg) were studied for development of new drug for migraine treatment. Four-week experiments were carried out on white rats of both sex, with intragastral administration of RU-31 water solution in the doses of 10 mg/kg and 100 mg/kg. On the 29th day the dose of tested compound equal to LD50 was administered to the animals. Due to the calculation of accumulation coefficient(more than 20 units) the tablet form of RU-31 shows the lack of cumulative properties.