Open AccessTHE ROLE OF ANGIOPOIETIN-LIKE PROTEINS IN THE DEVELOPMENT OF RENAL DYSFUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS AND METABOLIC CHANGES
Author(s) -
В. А. Александров,
Л. Н. Шилова,
А. В. Александров
Publication year - 2020
Publication title -
vestnik volgogradskogo gosudarstvennogo medicinskogo universiteta
Language(s) - English
Resource type - Journals
eISSN - 1994-9499
pISSN - 1994-9480
DOI - 10.19163/1994-9480-2020-4(76)-37-41
Subject(s) - rheumatoid arthritis , renal function , medicine , endocrinology , metabolic syndrome , kidney disease , inflammation , pathogenesis , kidney , immunology , physiology , biology , obesity
The article is devoted to the assessment of the relationship between the serum concentrations of angiopoietin-like proteins of types 3 and 4 (ANGPTL 3 and 4) and the development of renal dysfunction in patients with rheumatoid arthritis (RA) with metabolic changes. We examined 158 patients with RA (91,8 % – women and 8,2 % – men) aged 21 to 80 years old with the average duration of diseases – 9 [4–15] years. Negative correlations of average strength between the indices of the estimated glomerular filtration rate (eGFR) according to the 2009 CKD-EPI formula and the level of ANGPTL 3 (r = –0,32, p < 0,001) and ANGPTL 4 (rS = –0,31, p < 0,001) were revealed. It was found that renal dysfunction and the presence of metabolic syndrome (R 2 = 0,33) are the two factors which have a direct effect on the ANGPTL 4 concentration in RA patients’ serum. ANGPTL type 4 should be considered as a key factor linking the development of renal dysfunction and metabolic changes caused by rheumatoid inflammation