Open AccessMODERN PROBLEMS OF NISSUE DYSPLASIA IN CHILDREN PATHOGENESIS OF CONNECTIVE
Author(s) -
Nikolay Cherkasov,
Yu.A. Lutsenko,
M.Ya. Ledyaev,
T.N. Doronina,
А.V. Prakhov,
Ya.M. Ledyaev
Publication year - 2020
Publication title -
vestnik volgogradskogo gosudarstvennogo medicinskogo universiteta
Language(s) - English
Resource type - Journals
eISSN - 1994-9499
pISSN - 1994-9480
DOI - 10.19163/1994-9480-2020-4(76)-16-23
Subject(s) - pathogenesis , elastin , ctd , connective tissue , dysplasia , laminin , phenotype , connective tissue disease , biology , medicine , pathology , disease , genetics , extracellular matrix , gene , autoimmune disease , oceanography , geology
Pathogenesis connective tissue dysplasia (CTD) is an important pediatric issue. CTD is characterized by polymorpfism of phenotypic and visceral signs. Pathogenetic aspect connected with disbalance of collagenic and non-collagenic proteins deserve special attention when children have non-hereditary forms of CTD. The role of elastin and laminin disbalance and the genome «major proteins» that participate in tissue structures’ formation remains an understudied issue.