Open AccessEFFECT OF ADJUVANT PREPARATIONS ON THE EXPRESSION OF ANALGETIC ACTIVITY OF MORPHIN IN SOMATOGENIC PAIN
Author(s) -
Yu. V. Semenova,
Natalya Eliseeva,
Александр Алексеевич Спасов
Publication year - 2020
Publication title -
vestnik volgogradskogo gosudarstvennogo medicinskogo universiteta
Language(s) - English
Resource type - Journals
eISSN - 1994-9499
pISSN - 1994-9480
DOI - 10.19163/1994-9480-2020-4(76)-141-145
Subject(s) - metoclopramide , clonidine , diazepam , morphine , haloperidol , midazolam , anesthesia , gabapentin , medicine , atropine , opioid , pharmacology , (+) naloxone , nociception , sedation , vomiting , alternative medicine , receptor , pathology , dopamine
Combination of traditional opioid with coanalgesics is recommended to reduce the dose of analgesics and the side effects as well as the relief of different pain severity. In this study was evaluated the effectiveness of different adjuvant drugs: haloperidol (0,45 mg/kg), metoclopramide (5 mg/kg), gabapentin (90 mg/kg), diazepam (1 mg/kg), midazolam (0,3 mg/kg), clonidine (1 mg/kg), atropine (2,7 mg/kg) with subanalgesic dose of morphine (1 mg/kg) in the somatogenic pain test (somatogenic pain was modelled with tail-flick). It was shown that the severity of the antinociceptive effect of morphine was significantly increased when combined with haloperidol, clonidine, gabapentin and metoclopramide; did not change when co-administered with midazolam and atropine; decreased when combined with diazepam.