Open AccessHER2-positive breast cancer with brain metastasis: long-lasting response after lapatinib treatment
Author(s) -
A. D'Alonzo,
Claudia Bighin
Publication year - 2018
Publication title -
aboutopen
Language(s) - English
Resource type - Journals
ISSN - 2465-2628
DOI - 10.19156/abtpn.2018.0036
Subject(s) - lapatinib , medicine , capecitabine , pertuzumab , trastuzumab , oncology , trastuzumab emtansine , breast cancer , metastatic breast cancer , brain metastasis , radiation therapy , chemotherapy , lymph node , cancer , metastasis , colorectal cancer
We report the case of a 50-year-old patient diagnosed with breast cancer with lymph node, lymph node, pulmonary and hepatic secondaryisms. After receiving a first line chemotherapy containing taxanes, pertuzumab and trastuzumab, the patient developed asymptomatic brain metastases. She is therefore treated with panencephalic radiotherapy and second line treatment with trastuzumab emtansine. Further to systemic and cerebral disease progression, the patient is treated with capecitabine and lapatinib. This treatment lasted approximately 6 months with sustained efficacy on secondary lesions and an excellent tolerance profile (Oncology)