Open AccessPharmacogenetic Associations with ADME Variants and Virologic Response to an Initial HAART Regimen in HIV-Infected Women
Author(s) -
Celeste Leigh Pearce,
Douglas Stram,
Ashley Wiensch,
Melissa A. Frasco,
Naoko Kono,
David Van Den Berg,
Kathryn Anastos,
Mardge H. Cohen,
Jack DeHovitz,
Elizabeth T. Golub,
Bani Tamraz,
C Liu,
Wendy J. Mack
Publication year - 2017
Publication title -
international journal of hiv/aids and research
Language(s) - English
Resource type - Journals
ISSN - 2379-1586
DOI - 10.19070/2379-1586-1700031
Subject(s) - medicine , cohort , pharmacogenetics , regimen , protease inhibitor (pharmacology) , integrase inhibitor , viral load , immunology , adme , oncology , genotype , biology , virology , human immunodeficiency virus (hiv) , gene , pharmacokinetics , antiretroviral therapy , genetics
Clinical response to highly active antiretroviral therapy (HAART) varies among different populations. A portion of this variability may be due to variation in genes involved in the absorption, distribution, metabolism, and excretion (ADME) of HAART.