Open AccessStudying The Association Of Metformin Dose With Peripheral Neuropathy In Diabetic Patients At Jordanian Royal Medical Services
Author(s) -
Wafa'a Jamil abu Jama'ah,
Motazbellah Fat'hi Alzu'bi,
Alaa Rfeefan Alabbad,
Alaa Mohammed Al Mrayat,
Ola Ahmad Aldmour,
Jaafar Abu Abeeleh,
Ahed J Alkhatib
Publication year - 2016
Publication title -
european scientific journal
Language(s) - English
Resource type - Journals
eISSN - 1857-7881
pISSN - 1857-7431
DOI - 10.19044/esj.2016.v12n6p22
Subject(s) - metformin , medicine , peripheral neuropathy , vitamin b12 , diabetes mellitus , diabetic neuropathy , medical record , peripheral , endocrinology
The aim of the present study was to study the association of metformin dose with peripheral neuropathy in diabetic patients at Jordanian Royal Medical Services. A retrospective study was conducted to collect data from files of 392 diabetic patients at Jordanian Royal Medical Services. A working sheet was created for each patient that included the following information: gender, age, peripheral neuropathy, vitamin B12 status, metformin use, and metformin dose. Data were analyzed using SPSS version 20. Data were represented as frequencies and percentages for categorical variables such as gender, and vitamin B12 status; means and standard deviations for continuous variables such as age. The relationships between variables were examined using Chi-Square, and One Way Anova. Significance was considered at alpha level <0.05. Study findings showed that the prevalence of diabetic peripheral neuropathy among participants was about 43%. Vitamin B12 deficiency was about 7%. Diabetic peripheral neuropathy was significantly associated with gender (p=0.018). No significant associations were observed between peripheral neuropathy and vitamin B12 or metformin dose. Taken together, the results of the present study showed that treatment with metformin did not lead to vitamin B12 deficiency, although the prevalence of diabetic peripheral neuropathy was relatively high (about 43%).