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Clarithromycin as an Adjunct to One‐Stage Full‐Mouth Ultrasonic Periodontal Debridement in Generalized Aggressive Periodontitis: A Randomized Controlled Clinical Trial
Author(s) -
Andere Naira Maria Rebelatto Bechara,
Castro dos Santos Nídia Cristina,
Araujo Cássia Fernandes,
Mathias Ingrid Fernandes,
Taiete Tiago,
Casarin Renato Corrêa Viana,
Jardini Maria Aparecida Neves,
Shaddox Luciana Machion,
Santamaria Mauro Pedrine
Publication year - 2017
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2017.170165
Subject(s) - medicine , placebo , debridement (dental) , dentistry , randomized controlled trial , clarithromycin , gingival and periodontal pocket , porphyromonas gingivalis , periodontitis , adverse effect , clinical trial , pathology , alternative medicine , helicobacter pylori
Background: The aim of the present study is to evaluate the periodontal clinical and microbiologic responses and possible adverse effects of clarithromycin (CLM) combined with periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis. Methods: Forty patients were selected and randomly assigned into one of two groups: 1) CLM (n = 20): one‐stage full‐mouth ultrasonic debridement (FMUD) associated with CLM (500 mg, every 12 hours for 3 days); and 2) placebo (n = 20): FMUD associated with placebo pills. Clinical and microbiologic parameters were evaluated at baseline and 3 and 6 months postoperatively. Results: Both treatments presented statistically significant clinical and microbiologic improvements. However, the CLM group presented lower means of probing depth for pockets ≥7 mm at 6 months (4.0 ± 1.7 mm) compared with the placebo group (4.7 ± 1.3 mm) ( P = 0.04). In addition, the CLM group also presented greater reduction of Porphyromonas gingivalis ( Pg ) DNA counts at 6 months ( P = 0.0001). Conclusion: Results from this study suggest both treatments are effective; however, adjunct use of CLM to FMUD leads to better reduction of deep pockets and Pg at 6 months compared with FMUD alone.