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Gingival Inflammation and Salivary or Serum Granulocyte‐Secreted Enzymes in Patients With Polycystic Ovary Syndrome
Author(s) -
Akcalı Aliye,
Bostanci Nagihan,
Özçaka Özgun,
Gümüş Pınar,
ÖztürkCeyhan Banu,
Tervahartiala Taina,
Husu Heidi,
Buduneli Nurcan,
Sorsa Timo,
Belibasakis Georgios N.
Publication year - 2017
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2017.170043
Subject(s) - gingivitis , medicine , polycystic ovary , myeloperoxidase , periodontitis , endocrinology , inflammation , dentistry , obesity , insulin resistance
Background: The objective of this cross‐sectional study is to investigate levels of salivary and serum matrix metalloproteinase (MMP)‐9, myeloperoxidase (MPO), neutrophil elastase (NE), and MMP‐9/tissue inhibitor of MMP‐1 (TIMP)‐1 ratio in patients with polycystic ovary syndrome (PCOS) and systemically healthy controls in the presence or absence of gingivitis. Methods: Serum and salivary levels of these biomarkers were evaluated in the following: 1) periodontally healthy women with PCOS (n = 45); 2) women with PCOS and gingivitis (n = 35); 3) systemically and periodontally healthy women (n = 25); and 4) systemically healthy women with gingivitis (n = 20). Enzyme‐linked immunosorbent assay was used to determine levels of these biomarkers. A full‐mouth clinical periodontal evaluation was performed for each patient. Results: Salivary MMP‐9 and NE levels, as well as MMP‐9/TIMP‐1 ratios, were higher in the systemically healthy women with gingivitis compared with periodontally healthy women with PCOS ( P <0.001; P <0.01; and P <0.0001, respectively). Serum MMP‐9 and MPO levels were higher in women with PCOS and gingivitis compared with periodontally healthy women with PCOS ( P <0.05). Serum MMP‐9 levels were lower in healthy women with gingivitis than systemically and periodontally healthy women or women with PCOS and gingivitis ( P <0.05). PCOS groups exhibited a positive correlation among clinical periodontal parameters and serum MMP‐9 levels or salivary MPO, NE levels, and MMP‐9/MMP‐1 ratio. Correlation was negative among clinical periodontal parameters and serum MMP‐9 levels and MMP‐9/TIMP‐1 ratio in systemically healthy patients ( P <0.05). Conclusions: The present findings emphasize that PCOS and gingival inflammation are associated with each other, as evidenced by salivary and serum levels of neutrophilic enzymes. This interaction may contribute to the perturbation of ovarian remodeling in PCOS.