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Effect of Intensive Periodontal Therapy on Blood Pressure and Endothelial Microparticles in Patients With Prehypertension and Periodontitis: A Randomized Controlled Trial
Author(s) -
Zhou QianBing,
Xia WenHao,
Ren Jing,
Yu BingBo,
Tong XinZhu,
Chen YanBin,
Chen Shan,
Feng Lei,
Dai Jing,
Tao Jun,
Yang JunYing
Publication year - 2017
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2017.160447
Subject(s) - medicine , periodontitis , randomized controlled trial , blood pressure , bleeding on probing , randomization , prehypertension , confounding , gastroenterology , dentistry
Background: Although some studies show a positive association between periodontitis and blood pressure (BP) elevation, research on the effect of intensive periodontal treatment on decline in BP levels and endothelial microparticles (EMPs) without any antihypertensive management is lacking. Therefore, the present clinical trial explores whether intensive periodontal therapy would lower BP levels and EMPs of patients with prehypertension with periodontitis. Methods: From a total 107 patients, 95 underwent randomization (47 assigned to control‐treatment [CT] group and 48 assigned to intensive‐treatment [IT] group) and completed the trial. Patients received intervention for 4 consecutive weeks and were followed for 6 months. Levels of BP and EMPs were evaluated at baseline and 1, 3, and 6 months after intervention. Results: Periodontal conditions were significantly improved ( P <0.05) 6 months after intensive periodontal treatment. In parallel, the primary outcomes including systolic and diastolic BP and EMPs were markedly reduced in the IT group compared with the CT group (absolute difference: 12.57 and 9.65 mm Hg and 581.59/μL, respectively; 95% confidence intervals: 10.45 to 14.69, 7.06 to 12.24, and 348.12 to 815.06, respectively; P <0.05). Reduction in BP levels and EMPs was related to improvement in probing depth ( r = 0.358, 0.363, and 0.676, respectively, by the Pearson product‐moment correlation; P = 0.009, 0.008, and P <0.001, respectively). Conclusion: To the best knowledge of the authors, the present study demonstrates for the first time that intensive periodontal intervention without any antihypertensive medication therapy may be an effective means to lower levels of BP and EMPs in patients with prehypertension with periodontitis.