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Correlation Between Gingival Crevicular Fluid Hemoglobin Content and Periodontal Clinical Parameters
Author(s) -
Ito Hiroshi,
Numabe Yukihiro,
Hashimoto Shuichi,
Sekino Satoshi,
Murakashi Etsuko,
Ishiguro Hitomi,
Sasaki Daisuke,
Yaegashi Takashi,
Takai Hideki,
Mezawa Masaru,
Ogata Yorimasa,
Watanabe Hisashi,
Hagiwara Satsuki,
Izumi Yuichi,
Hiroshima Yuka,
Kido JunIchi,
Nagata Toshihiko,
Kunimatsu Kazushi
Publication year - 2016
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2016.160092
Subject(s) - medicine , hemoglobin , dentistry , correlation , gingival and periodontal pocket , periodontal disease , mathematics , geometry
Background: Probing depth (PD) and bleeding on probing (BOP) are essential clinical parameters used for periodontal diagnosis. This study investigated whether detection of hemoglobin (Hb) in gingival crevicular fluid (GCF), along with PD and BOP, would improve diagnostic accuracy. Methods: After plaque index (PI) was measured, GCF was collected from the gingival sulci of 401 anterior teeth in the maxilla and mandible from 184 patients who had entered periodontal maintenance therapy. Clinical parameters (gingival index [GI], PD, clinical attachment level [CAL], and BOP) were recorded. Hb values in GCF were assessed by immunochromatography. Moreover, cutoff values for PI, GI, and CAL based on the degree of PD and amount of GCF were created and analyzed. Results: Hb was detected in 64.8% of GCF samples in 105 BOP‐negative (–) sites in the periodontally stable group out of 107 sites that were less than all cutoff values. There were 71 BOP(–) sites in the periodontal‐management‐required group out of 122 sites that were more than all cutoff values, although no improvement in periodontal disease was observed. Hb was detected in 88.7% of GCF samples from these 71 BOP(–) sites. Conclusions: Hb was observed in more than 60% of GCF samples in BOP(–) gingival sulci in both periodontally stable and periodontal‐management‐required groups. These results suggest inspection of Hb derived from microbleeding in gingival sulci may serve as an index for preclinical diagnosis.