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Periodontal Disease and Incident Lung Cancer Risk: A Meta‐Analysis of Cohort Studies
Author(s) -
Zeng XianTao,
Xia LingYun,
Zhang YongGang,
Li Sheng,
Leng WeiDong,
Kwong Joey S.W.
Publication year - 2016
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2016.150597
Subject(s) - medicine , lung cancer , publication bias , meta analysis , cohort study , subgroup analysis , cohort , population , hazard ratio , funnel plot , cancer , confidence interval , oncology , environmental health
Background: Periodontal disease is linked to a number of systemic diseases such as cardiovascular diseases and diabetes mellitus. Recent evidence has suggested periodontal disease might be associated with lung cancer. However, their precise relationship is yet to be explored. Hence, this study aims to investigate the association of periodontal disease and risk of incident lung cancer using a meta‐analytic approach. Methods: PubMed, Scopus, and ScienceDirect were searched up to June 10, 2015. Cohort and nested case‐control studies investigating risk of lung cancer in patients with periodontal disease were included. Hazard ratios (HRs) were calculated, as were their 95% confidence intervals (CIs) using a fixed‐effect inverse‐variance model. Statistical heterogeneity was explored using the Q test as well as the I 2 statistic. Publication bias was assessed by visual inspection of funnel plots symmetry and Egger’s test. Results: Five cohort studies were included, involving 321,420 participants in this meta‐analysis. Summary estimates based on adjusted data showed that periodontal disease was associated with a significant risk of lung cancer (HR = 1.24, 95% CI = 1.13 to 1.36; I 2 = 30%). No publication bias was detected. Subgroup analysis indicated that the association of periodontal disease and lung cancer remained significant in the female population. Conclusion: Evidence from cohort studies suggests that patients with periodontal disease are at increased risk of developing lung cancer.