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Reducing Dental Plaque and Gingivitis With 0.6% Cortex Ilicis Rotundae Toothpaste: A Randomized, Double‐Masked Clinical Trial
Author(s) -
Liu Hongchun,
Yin Wei
Publication year - 2016
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2015.150414
Subject(s) - toothpaste , gingivitis , medicine , placebo , dentistry , adverse effect , randomized controlled trial , dental plaque , pathology , alternative medicine
Background: Cortex Ilicis Rotundae has antioxidant and anti‐inflammatory properties. Few studies have evaluated the effects of toothpastes containing Cortex Ilicis Rotundae . This study evaluates the antiplaque and antigingivitis effects of a test toothpaste containing 0.6% Cortex Ilicis Rotundae extract in a calcium carbonate base compared with a control toothpaste without any active ingredient. Methods: One hundred adults with a mean plaque index (PI) ≥1.5 and a mean gingival index (GI) ≥1.0 were enrolled in this randomized, double‐masked, placebo‐controlled clinical trial. They were assigned randomly to use a test toothpaste or a control toothpaste. At baseline, 6 weeks, and 12 weeks, they received examinations of oral hard and soft tissues, using Löe‐Silness GI for gingivitis and the Turesky modification of the Quigley‐Hein PI for PI. Adverse events were monitored. Results: When the study was completed, the test group reported lower mean GI than the control group (1.13 ± 0.22 versus 1.30 ± 0.23; P = 0.001) and lower mean PI than the control group (2.53 ± 0.5 versus 2.93 ± 0.44; P <0.001). Compared to the baseline, the test group had reductions in GI and PI of 14.39% and 17.86%, respectively (both P <0.001); the control group had reductions in GI and PI of 3.7% and 3.93%, respectively (both P <0.001). No adverse events were reported during the course of the study. Conclusion: The toothpaste containing 0.6% Cortex Ilicis Rotundae was effective in reducing dental plaque and gingivitis after 12 weeks of use compared with a negative control toothpaste.