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Meta‐Analysis of Association Between Interleukin‐1β C‐511T Polymorphism and Chronic Periodontitis Susceptibility
Author(s) -
Zeng XianTao,
Liu DongYan,
Kwong Joey S. W.,
Leng WeiDong,
Xia LingYun,
Mao Min
Publication year - 2015
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2015.140698
Subject(s) - odds ratio , meta analysis , confidence interval , chronic periodontitis , medicine , subgroup analysis , gastroenterology , periodontitis , aggressive periodontitis , polymorphism (computer science) , genetic association , case control study , genetic model , bioinformatics , genotype , genetics , single nucleotide polymorphism , biology , gene
Background: Many studies have been conducted to explore the association between interleukin ( IL)‐1β C‐511T polymorphism and risk of chronic periodontitis (CP) but with different or even contradictory results. A meta‐analysis was performed to further explore their association. Methods: PubMed, Chinese National Knowledge Infrastructure, and EMBASE were searched up to September 30, 2014 for relevant case‐control studies. Two authors (D‐YL and L‐YX) independently selected studies and extracted data from included studies. The meta‐analysis was performed using comprehensive meta‐analysis software. Results: Nineteen case‐control studies involving 2,173 patients with CP and 3,900 healthy controls were included. Using a random‐effects meta‐analysis model, a non‐significant association between IL‐1β C‐511T polymorphism and CP was identified (T versus C: odds ratio [OR] = 1.03, 95% confidence interval [CI] = 0.85 to 1.25; TT versus CC: OR = 1.03, 95% CI = 0.72 to 1.46; CT versus CC: OR = 0.96, 95% CI = 0.71 to 1.30; CT + TT versus CC: OR = 1.00, 95% CI = 0.74 to 1.34; TT versus CT + CC: OR = 1.05, 95% CI = 0.81 to 1.38), and sensitivity analysis indicated that the results were robust. Subgroup analyses also revealed a non‐significant association. No publication bias was detected. Conclusions: Based on currently available evidence, IL‐1β C‐511T polymorphism is not associated with the risk of developing CP. Additional research is warranted to further explore and confirm the association of genetic polymorphism and CP.