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Estimation of Bone Loss Biomarkers as a Diagnostic Tool for Peri‐Implantitis
Author(s) -
Rakic Mia,
Struillou Xavier,
PetkovicCurcin Aleksandra,
Matic Smiljana,
Canullo Luigi,
Sanz Mariano,
Vojvodic Danilo
Publication year - 2014
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2014.140069
Subject(s) - sclerostin , osteoprotegerin , mucositis , peri implantitis , rankl , medicine , implant , dentistry , chemistry , receptor , activator (genetics) , radiation therapy , surgery , biochemistry , wnt signaling pathway , gene
Background: The aims of this study are to estimate the profile of bone loss biomarkers in peri‐implant tissues and to identify potential prognostic biomarkers of peri‐implantitis. Methods: Peri‐implant crevicular fluid samples collected from 164 participants (52 patients with peri‐implantitis, 54 with mucositis, and 58 with healthy peri‐implant tissues) were analyzed using enzyme‐linked immunosorbent assays to evaluate concentrations of the receptor activator of nuclear factor‐κB (RANK), soluble RANK ligand (sRANKL), osteoprotegerin (OPG), cathepsin‐K, and sclerostin. Results: Concentrations of RANK, sRANKL, OPG, and sclerostin were significantly increased in patients with peri‐implantitis compared with patients with healthy peri‐implant tissues. Comparisons between peri‐implantitis and mucositis demonstrated significantly higher values of sclerostin in peri‐implantitis samples. Comparisons between mucositis and healthy peri‐implant tissues showed significantly increased levels of RANK and cathepsin‐K in mucositis. Conclusion: These results are suggestive of a role of sRANKL, OPG, and sclerostin as prognostic biomarkers in peri‐implantitis.