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Generation of Site‐Appropriate Tissue by a Living Cellular Sheet in the Treatment of Mucogingival Defects
Author(s) -
Scheyer E. Todd,
Nevins Marc L.,
Neiva Rodrigo,
Cochran David L.,
Giannobile William V.,
Woo SookBin,
King William N.,
Spitznagel John K.,
Bates Damien,
McGuire Michael K.
Publication year - 2014
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2013.130348
Subject(s) - medicine , scar tissue , oral mucosa , dentistry , alveolar mucosa , oral cavity , wound healing , hard palate , pathology , surgery
Background: Generation of site‐appropriate tissue in the oral cavity includes the restoration of the correct anatomic type, amount, and distribution of the tissue. This study is a post hoc analysis of data collected during previously published results from two randomized clinical trials of a living cellular sheet (LCS; allogenic cultured keratinocytes and fibroblasts in bovine collagen) versus a free gingival graft (FGG), evaluating their ability to augment keratinized tissue or gingiva. Methods: Post hoc histologic and clinical (photographic) comparisons of the outcomes of treatment were performed on histologic and photographic data gathered in the two randomized clinical trials. Results: Histologic findings showed that LCS‐treated sites resembled gingiva rather than alveolar mucosa. Photographic analysis indicated that LCS treatment resulted in more site‐appropriate tissue than FGG in terms of tissue color, with adjacent untreated tissue, absence of scar formation or keloid‐like appearance, and mucogingival junction alignment. Conclusion: Treatment of mucogingival defects with LCS resulted in the generation of tissue that is more site appropriate than tissue transplanted from the palate.