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Effect of Nanoscale Topography of Titanium Implants on Bone Vessel Network, Osteocytes, and Mineral Densities
Author(s) -
Traini Tonino,
Murmura Giovanna,
Piattelli Maurizio,
Scarano Antonio,
Pettinicchio Marzia,
Sinjari Bruna,
Caputi Sergio
Publication year - 2013
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2013.120627
Subject(s) - implant , bone mineral , osteocyte , osseointegration , dentistry , bone density , microstructure , materials science , medicine , osteoporosis , chemistry , surgery , osteoblast , composite material , biochemistry , in vitro
Background: Chemical and physical properties of an implant surface have a major influence on the structure of peri‐implant bone and thus may influence the clinical performance of the implant. This study aims to evaluate the bone microstructure around implants with and without added nanometer‐sized calcium phosphate particles. Methods: An implant with dual acid‐etched surface (control) and an implant with dual acid‐etched surface and CaP nanoparticles (test) were placed in the posterior maxilla of 15 patients. Bone microstructure was evaluated for osteocyte density (OD), bone vessel volume density (BVVD), and bone mineral density (BMD). Results: BVVD was 1.806 ± 0.05 for test implants and 1.533 ± 0.10 for control implants ( P <0.001). BMD low was 17.4 × 10 4 µm 2 for test implants and 15.0 × 10 4 µm 2 for control implants ( P = 0.025). Results from the BMD high comparison, test versus control, were not statistically significant ( P >0.05). OD was 575.6 ± 63.7 mm 2 for test implants and 471.2 ± 61.9 mm 2 for control implants ( P <0.001). Conclusions: After 8 weeks of healing, the bone microstructure around test implants appeared to be significantly more organized. Clinical implications of these results include shortened healing time and indication for earlier loading protocols.