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Thermo‐Reversible Green Tea Catechin Gel for Local Application in Chronic Periodontitis: A 4‐Week Clinical Trial
Author(s) -
Chava Vijay Kumar,
Vedula Bhargavi Devi
Publication year - 2013
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2012.120425
Subject(s) - catechin , chronic periodontitis , medicine , statistical significance , placebo , periodontitis , green tea extract , green tea , gastroenterology , polyphenol , clinical significance , dentistry , randomized controlled trial , chemistry , food science , antioxidant , pathology , biochemistry , alternative medicine
Background: Green tea extract is a naturally occurring antimicrobial agent, consisting of polyphenols (catechin) with anticariogenic, anti‐inflammatory, anticollagenolytic properties. Hence, in the present study, an attempt was made to develop a thermo‐reversible sustained‐release green tea gel and to study its clinical effects on patients with chronic periodontitis (CP). Methods: Thermo‐reversible sustained‐release green tea catechin gel was prepared and tested for its in vitro release characteristics. An in vivo controlled, randomized, split‐mouth single‐evaluator masked study was conducted. Thirty patients with two sites in the contralateral quadrants having probing depths (PDs) of ≥4 mm were selected. Assessment of gingival index (GI), PD, and relative clinical attachment levels (rCALs) was done at baseline and at 4 weeks. Green tea and placebo gels were placed at test and control sites as an adjunct to Phase 1 periodontal therapy. Results: Comparison of the mean ± SD GI, PD, and rCAL values within the test group at baseline (1.92 ± 0.24, 4.93 ± 0.58, and 9.97 ± 0.72, respectively) and the end of 4 weeks (0.01 ± 0.04, 2.87 ± 0.51, and 7.87 ± 0.51, respectively) showed high statistical significance ( P <0.001). Comparison of mean ± SD of GI, PD, and rCAL within the control group at baseline (1.95 ± 0.16, 4.77 ± 0.50, and 9.73 ± 0.45, respectively) and the end of 4 weeks (0.16 ± 0.11, 3.8 ± 0.48, and 8.76 ± 0.43, respectively) showed significance with P <0.001. High significance was observed between the delta of measurements (0 to 4 weeks) of GI, PD, and rCAL between test (1.91 ± 0.20, 2.06 ± 0.07, and 2.1 ± 0.21, respectively) and control (1.79 ± 0.05, 0.97 ± 0.02, and 0.97 ± 0.02, respectively) groups. Conclusion: Adjunctive local drug therapy with thermo‐reversible green tea gel has shown to reduce pockets and inflammation during the 4 weeks of the clinical trial in patients with CP.