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Clinical Efficacy of Subgingivally Delivered 1.2‐mg Simvastatin in the Treatment of Individuals With Class II Furcation Defects: A Randomized Controlled Clinical Trial
Author(s) -
Pradeep A.R.,
Priyanka N.,
Kalra Nitish,
Naik Savitha B.,
Singh Sonender P.,
Martande Santosh
Publication year - 2012
Publication title -
journal of periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.036
H-Index - 156
eISSN - 1943-3670
pISSN - 0022-3492
DOI - 10.1902/jop.2012.110716
Subject(s) - medicine , dentistry , furcation defect , randomized controlled trial , simvastatin , placebo , scaling and root planing , clinical trial , bleeding on probing , periodontitis , molar , chronic periodontitis , alternative medicine , pathology
Background: Simvastatin (SMV) assists in bone regeneration and has an anti‐inflammatory effect when delivered or applied locally. The present clinical trial is designed to investigate the effectiveness of 1.2‐mg SMV as a local drug delivery system as an adjunct to scaling and root planing (SRP) for the treatment of Class II furcation defects. Methods: Seventy‐two patients with mandibular buccal Class II furcation defects were randomized and categorized into two treatment groups: SRP plus placebo (group 1) and SRP plus 1.2‐mg SMV (group 2). Clinical parameters were recorded at baseline before SRP and at 3 and 6 months; they included modified sulcus bleeding index (mSBI), probing depth (PD), and relative vertical (RVAL) and horizontal (RHAL) attachment levels. At baseline and after 6 months, radiologic assessment of bone defect fill was performed. Results: Both therapies resulted in significant improvements. The decrease in mSBI score at 6 months was greater in group 2 (2.02 ± 0.23) compared with group 1 (1.80 ± 0.22). The mean decrease in PD at 6 months was 1.30 ± 1.0 and 4.05 ± 1.31 mm in groups 1 and 2, respectively. A significantly greater gain in mean RVAL and RHAL was found in group 2 than in group 1 ( P <0.05). Furthermore, significantly greater mean percentage of bone fill was found in group 2 (25.16%) compared with group 1 (1.54%). Conclusion: Locally delivered SMV provides a comfortable and flexible method to improve clinical parameters and also to enhance bone formation.